Genc, Sertac; Gulcemal, Suleyman; Gunnaz, Salih; Cetinkaya, Bekir; Gulcemal, Derya published the artcile< Synthesis of α-Alkylated Ketones via Selective Epoxide Opening/Alkylation Reactions with Primary Alcohols>, Category: alcohols-buliding-blocks, the main research area is ketone alkyl preparation regioselective; alc primary epoxide opening alkylation reaction NHC iridium catalyst.
A new method for converting terminal epoxides I (R = Ph, naphthalen-2-yl, decyl, etc.) and primary alcs. R1CH2OH (R1 = hexyl, 2-aminophenyl, thiophen-2-yl, 3-ferrocenyl, etc.) into α-alkylated ketones RC(O)(CH2)2R1, 3,3′-(1,4-phenylene)bis(1-phenylpropan-1-one) and 2-phenylquinoline under borrowing hydrogen conditions is reported. The procedure involves a one-pot epoxide ring opening and alkylation via primary alcs. in the presence of an N-heterocyclic carbene iridium(I) catalyst, under aerobic conditions, with water as the side product.
Organic Letters published new progress about Alkylation catalysts, regioselective. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts