Durgadevi, Ravindran; Veera Ravi, Arumugam; Alexpandi, Rajaiah; Krishnan Swetha, Thirukannamangai; Abirami, Gurusamy; Vishnu, Selvam; Karutha Pandian, Shunmugaiah published the artcile< Virulence targeted inhibitory effect of linalool against the exclusive uropathogen Proteus mirabilis>, Related Products of 78-70-6, the main research area is urinary tract infection linalool proteus biofilm virulence; Antibiofilm activity; antivirulence activity; crystalline biofilm; linalool; motility; proteus.
Proteus mirabilis is one of the leading causes of catheter-associated UTIs (CAUTI) in individuals with prolonged urinary catheterization. Since, biofilm assisted antibiotic resistance is reported to complicate the treatment strategies of P. mirabilis infections, the present study was aimed to attenuate biofilm and virulence factor production in P. mirabilis. Linalool is a naturally occurring monoterpene alc. found in a wide range of flowers and spice plants and has many biol. applications. In this study, linalool exhibited concentration dependent anti-biofilm activity against crystalline biofilm of P. mirabilis through reduced production of the virulence enzyme urease that raises the urinary pH and drives the formation of crystals (struvite) in the biofilm. The results of q-PCR anal. unveiled the down regulation of biofilm/virulence associated genes upon linalool treatment, which was in correspondence with the in vitro bioassays. Thus, this study reports the feasibility of linalool acting as a promising anti-biofilm agent against P. mirabilis mediated CAUTI.
Biofouling published new progress about Biofilms (microbial). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Related Products of 78-70-6.
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