《Chelation Crosslinking of Biodegradable Elastomers》 was published in Advanced Materials (Weinheim, Germany) in 2020. These research results belong to Chen, Ying; Miller, Paula G.; Ding, Xiaochu; Stowell, Chelsea E. T.; Kelly, Katie M.; Wang, Yadong. Safety of 2-Aminopropane-1,3-diol The article mentions the following:
Widely present in nature and in manufactured goods, elastomers are network polymers typically crosslinked by strong covalent bonds. Elastomers crosslinked by weak bonds usually exhibit more plastic deformation. Here, chelation as a mechanism to produce biodegradable elastomers is reported. Polycondensation of sebacic acid, 1,3-propanediol, and a Schiff-base (2-[[(2-hydroxyphenyl) methylene]amino]-1,3-propanediol) forms a block copolymer that binds several biol. relevant metal ions. Chelation offers a unique advantage unseen in conventional elastomer design because one ligand binds multiple metal ions, yielding bonds of different strengths. Therefore, one polymeric ligand coordinated with different metal ions produces elastomers with vastly different characteristics. Mixing different metal ions in one polymer offers another degree of control on material properties. The d. of the ligands in the block copolymer further regulates the mech. properties. Moreover, a murine model reveals that Fe3+ crosslinked foam displays higher compatibility with s.c. tissues than the widely used biomaterial-polycaprolactone. The implantation sites restore to their normal architecture with little fibrosis upon degradation of the implants. The versatility of chelation-based design has already shown promise in hydrogels and highly stretchy nondegradable polymers. The biodegradable elastomers reported here would enable new materials and new possibilities in biomedicine and beyond. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Safety of 2-Aminopropane-1,3-diol)
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Safety of 2-Aminopropane-1,3-diol
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