Chen, Jian; Zhu, Shaolin published the artcile< Nickel-Catalyzed Multicomponent Coupling: Synthesis of α-Chiral Ketones by Reductive Hydrocarbonylation of Alkenes>, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is alpha ketone preparation regio chemo enantioselective; alkene benzyl chloride ethyl chloroformate reductive hydroformylation carbonylation nickel; NHP ester amino acid alkene propylchloroformate reductive hydroformylation carbonylation.
A nickel-catalyzed, multicomponent regio- and enantioselective coupling via sequential hydroformylation and carbonylation from readily available starting materials has been developed. This modular multicomponent hydrofunctionalization strategy enables the straightforward reductive hydrocarbonylation of a broad range of unactivated alkenes to produce a wide variety of unsym. dialkyl ketones bearing a functionalized α-stereocenter, including enantioenriched chiral α-aryl ketones and α-amino ketones. It uses chiral bisoxazoline as a ligand, silane as a reductant, chloroformate as a safe CO source, and a racemic secondary benzyl chloride or an N-hydroxyphthalimide (NHP) ester of a protected α-amino acid as the alkylation reagent. The benign nature of this process renders this method suitable for late-stage functionalization of complex mols.
Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts