Chang, Zhiqian; Zhu, Huilong; Wu, Changhui; Xing, Junhao; Dou, Xiaowei published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《A rhodium-catalyzed conjugate addition/cyclization cascade for the asymmetric synthesis of 2-amino-4H-chromenes》.Electric Literature of C6H7BO3 The article contains the following contents:
The enantioselective synthesis of 2-amino-4H-chromenes via the cascade rhodium-catalyzed conjugate addition/hetero Thorpe-Ziegler reaction is reported. Moderate to good yields (up to 98%) and high enantioselectivities (up to 92% ee) were obtained with a chiral diene-coordinated rhodium complex as the catalyst. This protocol remedies the methodol. deficiency in the asym. synthesis of 4-aryl 2-amino-4H-chromenes. In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Electric Literature of C6H7BO3)
2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Electric Literature of C6H7BO3
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