Beni, Ryan; Boadi, William; Karim, Kaleh; Alnakhli, Jawzah; Alhamed, Samiyah published the artcile< Synthesis and antiproliferative activities of triphenylmethanol conjugates of leuprorelin>, Formula: C19H16O, the main research area is leuprorelin triphenylmethanol conjugate antiproliferative invasive ductal prostate carcinoma adipocyte.
Leuprorelin (LEP) is an FDA drug for breast cancer and prostate cancer treatment. There are several reported adverse effects such as transient hypertension, excessive salivation, and increased dysuria during treatment with LEP. In this study, the efficacy and toxicity of LEP were modified by using a drug delivery system to adjust the physicochem. properties. In this regard, Leuprorelin conjugates of triphenylmethanol derivatives (TPMs) were synthesized as prodrugs. Comparative antiproliferative assays showed that LEP-TPMs conjugates had significantly higher antiproliferative activities than the corresponding non-covalent phys. mixtures of the TPMs and LEP against human invasive ductal carcinoma (BT549), human prostate carcinoma (PC3), human lung cancer (A549) and mouse pre-adipocytes (3T3-L1) cells.
Open Journal of Medicinal Chemistry published new progress about Adipocyte, preadipocyte. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Formula: C19H16O.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts