HPLC of Formula: 89466-08-0In 2020 ,《Discovery of 4,6- and 5,7-Disubstituted Isoquinoline Derivatives as a Novel Class of Protein Kinase C ζ Inhibitors with Fragment-Merging Strategy》 appeared in Journal of Medicinal Chemistry. The author of the article were Atobe, Masakazu; Serizawa, Takayuki; Yamakawa, Natsumi; Takaba, Kenichiro; Nagano, Yukiko; Yamaura, Toshiaki; Tanaka, Eiichi; Tazumi, Atsutoshi; Bito, Shino; Ishiguro, Masashi; Kawanishi, Masashi. The article conveys some information:
Two chem. series of novel protein kinase C ζ (PKCζ) inhibitors, 4,6-disubstituted and 5,7-disubstituted isoquinolines, were rapidly identified using our fragment merging strategy. This methodol. involves biochem. screening of a high concentration of a monosubstituted isoquinoline fragment library, then merging hit isoquinoline fragments into a single compound Our strategy can be applied to the discovery of other challenging kinase inhibitors without protein-ligand structural information. Furthermore, our optimization effort identified the highly potent and orally available 5,7-isoquinoline 37(I) from the second chem. series. Compound 37 showed good efficacy in a mouse collagen-induced arthritis model. The in vivo studies suggest that PKCζ inhibition is a novel target for rheumatoid arthritis (RA) and that 5,7-disubstituted isoquinoline 37 has the potential to elucidate the biol. consequences of PKCζ inhibition, specifically in terms of therapeutic intervention for RA. The experimental process involved the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0HPLC of Formula: 89466-08-0)
2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. HPLC of Formula: 89466-08-0
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