Agarwal, Sameer; Sasane, Santosh; Deshmukh, Prashant; Rami, Bhadresh; Bandyopadhyay, Debdutta; Giri, Poonam; Giri, Suresh; Jain, Mukul; Desai, Ranjit C. published their research in ACS Medicinal Chemistry Letters on December 8 ,2016. The article was titled 《Identification of an Orally Efficacious GPR40/FFAR1 Receptor Agonist》.SDS of cas: 865233-35-8 The article contains the following contents:
GPR40/FFAR1 is a G protein-coupled receptor predominantly expressed in pancreatic β-cells and activated by long-chain free fatty acids, mediating enhancement of glucose-stimulated insulin secretion. A novel series of substituted 3-(4-aryloxyaryl)propanoic acid derivatives were prepared and evaluated for their activities as GPR40 agonists, leading to the identification of compound 5, which is highly potent in in vitro assays and exhibits robust glucose lowering effects during an oral glucose tolerance test in nSTZ Wistar rat model of diabetes (ED50 = 0.8 mg/kg; ED90 = 3.1 mg/kg) with excellent pharmacokinetic profile, and devoid of cytochromes P 450 isoform inhibitory activity. In the experiment, the researchers used (S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid(cas: 865233-35-8SDS of cas: 865233-35-8)
(S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid(cas: 865233-35-8) belongs to alkynes. The addition of nonpolar E−H bonds across C≡C is general for silanes, boranes, and related hydrides.SDS of cas: 865233-35-8 The hydroboration of alkynes gives vinylic boranes which oxidize to the corresponding aldehyde or ketone. In the thiol-yne reaction the substrate is a thiol.
Referemce:
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Alcohols – Chemistry LibreTexts