The author of 《Mitochondrial-targeted Hsp90 C-terminal inhibitors manifest anti-proliferative activity》 were Zhang, Zheng; Banerjee, Monimoy; Davis, Rachel E.; Blagg, Brian S. J.. And the article was published in Bioorganic & Medicinal Chemistry Letters in 2019. Application In Synthesis of 3-Bromopropan-1-ol The author mentioned the following in the article:
The development of C-terminal heat shock protein 90 kDa (Hsp90) inhibitors has emerged as a potential treatment for cancer. Similarly, small mols. that target the mitochondria have proven to be efficacious towards cancer, as the reprogramming of mitochondrial function is often associated with oncogenic transformation. Herein, we report the development of triphenylphosphonium (TPP)-conjugated Hsp90 C-terminal inhibitors, their anti-proliferative activity, and accumulation in the mitochondria. In general, TPP-conjugated Hsp90 C-terminal inhibitors were found to manifest increased activity against various cancer cell lines when compared to the parent compounds In the experimental materials used by the author, we found 3-Bromopropan-1-ol(cas: 627-18-9Application In Synthesis of 3-Bromopropan-1-ol)
3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Application In Synthesis of 3-Bromopropan-1-ol
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