Xie, Dong-Tai; Chen, Hong-Lei; Wei, Dian; Wei, Bang-Yi; Li, Zheng-Hu; Zhang, Jian-Wu; Yu, Wei; Han, Bing published the artcile< Regioselective Fluoroalkylphosphorylation of Unactivated Alkenes by Radical-Mediated Alkoxyphosphine Rearrangement>, Reference of 627-27-0, the main research area is regioselective fluoroalkyl phosphorylation unactivated alkene radical alkoxyphosphine rearrangement; fluoroiodoalkyl phosphine oxide preparation crystal mol structure; Alkenes; Multicomponent Reactions; Radicals; Reaction Mechanisms; Regioselectivity.
A novel distal radical rearrangement of alkoxyphosphine is developed for the first time and applied to the regioselective radical fluoroalkylphosphorylation of unactivated olefins. By employing a one-pot two-step reaction of (bis)homoallylic alcs., organophosphine chlorides, and fluoroalkyl iodides under CFL (compact fluorescence light) irradiation, a series of fluoroalkylphosphorylated alkyl iodides and alcs. are easily synthesized by regiospecific installing a phosphonyl onto the inner carbon of terminal olefins and further iodination/hydroxylation. Mechanism studies reveal that the migration undergoes a distinctive radical cyclization/β-scission on the lone electron pair of phosphorus, resulting in C-P bond formation and C-O bond cleavage.
Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Reference of 627-27-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts