《An Imidazolium-Based Lipid Analogue as a Gene Transfer Agent》 was written by Paulisch, Tiffany O.; Bornemann, Steffen; Herzog, Marius; Kudruk, Sergej; Roling, Lena; Linard Matos, Anna Livia; Galla, Hans-Joachim; Gerke, Volker; Winter, Roland; Glorius, Frank. Electric Literature of C6H15NO And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:
A dicationic imidazolium salt is described and investigated towards its application for gene transfer. The polar head group and the long alkyl chains in the backbone contribute to a lipid-like behavior, while an alkyl ammonium group provides the ability for crucial electrostatic interaction for the transfection process. Detailed biophys. studies regarding its impact on biol. membrane models and the propensity of vesicle fusion are presented. Fluorescence spectroscopy, at. force microscopy and confocal fluorescence microscopy show that the imidazolium salt leads to negligible changes in lipid packing, while displaying distinct vesicle fusion properties. Cell culture experiments reveal that mixed liposomes containing the novel imidazolium salt can serve as plasmid DNA delivery vehicles. In contrast, a structurally similar imidazolium salt without a second pos. charge showed no ability to support DNA transfection into cultured cells. Thus, we introduce a novel and variable structural motif for cationic lipids, expanding the field of lipofection agents. In the experimental materials used by the author, we found 6-Aminohexan-1-ol(cas: 4048-33-3Electric Literature of C6H15NO)
6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Electric Literature of C6H15NO
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