In 1974,Okutani, Tetsuya; Kaneko, Tatsuhiko; Masuda, Katsutada published 《Azetidine derivatives. I. Synthesis o f 3-substituted azetidine derivatives》.Chemical & Pharmaceutical Bulletin published the findings.Formula: C3H8ClNO The information in the text is summarized as follows:
The azetidinols I (R = OH; R1 = Me2CH, Me3C, cyclohexyl, PhCHMe; R2 = H) were prepared by treating R1NH2 with epichlorohydrin followed by MeCN. I (R = OH, R1 = Et, R2 = H) was prepared from I (R = OH, R1 = R2 = H) and EtI. cis- and trans-I (R = OH, R1 = cyclohexyl, R2 = Ph) were prepared by bromination of PhCH:CHCH2Cl followed by treatment with cyclohexylamine. I (R = OH; R1 = Me2CH, Me3C, tert-octyl, cyclohexyl, PhCHMe, 1-adamantyl; R2 = H) were converted to I [R = MeSO3, NH2, CN, CO2H, NHC(:NH)NH2]. I [R = NHC(:NH)NH2] were antihypertensives (no data). In the experiment, the researchers used many compounds, for example, Azetidin-3-ol hydrochloride(cas: 18621-18-6Formula: C3H8ClNO)
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Formula: C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
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