Naito, Youichiro; Sugiura, Masanori; Yamaura, Yasunari; Fukaya, Chikara; Yokoyama, Kazumasa; Nakagawa, Yoshiaki; Ikeda, Tokuji; Senda, Mitsugi; Fujita, Toshio published an article in Chemical & Pharmaceutical Bulletin. The title of the article was 《Quantitative structure-activity relationship of catechol derivatives inhibiting 5-lipoxygenase》.Safety of 4-Butylbenzene-1,2-diol The author mentioned the following in the article:
Various catechol derivatives (β-substituted 3,4-dihydroxystyrenes, 1-substituted 3,4-dihydroxybenzenes, and 6-substituted 2,3-dihydroxynaphthalenes) were synthesized and their inhibition of 5-lipoxygenase was assayed. Their structure-activity relationships were examined quant. with substituent and structural parameters and regression anal. The variations of the inhibitory activity were explained in bilinear hydrophobic parameter (log P) terms, and steric (mol. thickness) and electronic (1H-NMR chem. shift of the proton adjacent to the catechol group) parameter terms. The hydrophobicity of the inhibitor mol. was important, and the optimum value of log P was ∼4.3-4.6, beyond which inhibition did not increase further. A lower electron d. of the aromatic ring containing the catechol group and the greater thickness of the lipophilic side chains were unfavorable to the activity. The results added a physicochem. basis for the selection of candidate compounds for developmental studies. In the experimental materials used by the author, we found 4-Butylbenzene-1,2-diol(cas: 2525-05-5Safety of 4-Butylbenzene-1,2-diol)
4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry.Safety of 4-Butylbenzene-1,2-diol Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities.
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