Modukuri, Ram K.; Choudhary, Dharmendra; Gupta, Sampa; Rao, K. Bhaskara; Adhikary, Sulekha; Sharma, Tanuj; Siddiqi, Mohammad Imran; Trivedi, Ritu; Sashidhara, Koneni V. published their research in Bioorganic & Medicinal Chemistry on December 15 ,2017. The article was titled 《Benzofuran-dihydropyridine hybrids: A new class of potential bone anabolic agents》.Recommanded Product: 153759-59-2 The article contains the following contents:
A series of novel benzofuran-dihydropyridine hybrids were designed by mol. hybridization approach and evaluated for bone anabolic activities. Among the screened library, compound I significantly enhanced the ALP production and mineralized nodule formation, which are primary requisites in the process of in vitro osteogenesis. Oral administration of compound I at 10 mg·kg-1·day-1 for two weeks led to restoration of trabecular bone microarchitecture in drill hole fracture model by significantly increasing BV/TV and Tb. N. Furthermore, histol. and mol. studies showed compound I triggering the new bone regeneration in a drill hole defect site by increasing BMP expression. Furthermore, mol. modeling studies were performed to gain insight into the binding approach, which revealed that both benzofuran and dihydropyridine moieties are essential to show similar binding interactions to fit into the active site of BMP2 receptor, an important target of the osteogenic agents. The results suggest that compound I stimulates BMP2 synthesis in osteoblast cells that promotes new bone formation (∼40%) at the fracture site which helps in shorten the healing period. The experimental process involved the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Recommanded Product: 153759-59-2)
5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Recommanded Product: 153759-59-2Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts