Medve, Laura; Achilli, Silvia; Guzman-Caldentey, Joan; Thepaut, Michel; Senaldi, Luca; Le Roy, Aline; Sattin, Sara; Ebel, Christine; Vives, Corinne; Martin-Santamaria, Sonsoles; Bernardi, Anna; Fieschi, Franck published the artcile< Enhancing Potency and Selectivity of a DC-SIGN Glycomimetic Ligand by Fragment-Based Design: Structural Basis>, Safety of (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride, the main research area is pseudo dimannoside design synthesis DCSIGN ligand selective antagonist; DC-SIGN; carbohydrates; glycomimetics; ligand design; virtual screening.
Chem. modification of pseudo-dimannoside ligands guided by fragment-based design allowed for the exploitation of an ammonium-binding region in the vicinity of the mannose-binding site of DC-SIGN, leading to the synthesis of a glycomimetic antagonist, I, of unprecedented affinity and selectivity against the related lectin langerin. Here, the computational design of pseudo-dimannoside derivatives as DC-SIGN ligands, their synthesis, their evaluation as DC-SIGN selective antagonists, the biophys. characterization of the DC-SIGN/I complex, and the structural basis for the ligand activity are presented. On the way to the characterization of this ligand, an unusual bridging interaction within the crystals shed light on the plasticity and potential secondary binding sites within the DC-SIGN carbohydrate recognition domain.
Chemistry – A European Journal published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Safety of (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts