Mattocks, A. R. published the artcile< Liver cell enlargement in rats given hydroxymethylpyrroles analogous to pyrrolizidine alkaloid metabolites, followed later by the hepatotoxin dimethylnitrosamine>, Electric Literature of 52160-51-7, the main research area is hydroxymethylpyrrole DMN liver.
Male rats aged 4-5 wk were given single doses of pyrrolic alcs. having alkylating properties similar to those of pyrrolizidine alkaloid metabolites, followed several days later by 1 of the hepatotoxins, DMN [62-75-9], thioacetamide (TA) [62-55-5] or CCl4 [56-23-5]. After 24-32 days the livers of animals given the pyrroles 1-methyl-2,3-bis(hydroxymethyl)pyrrole (I) [53365-77-8] or 1-phenyl-5-methyl-2,3-bis(hydroxymethyl)pyrrole (II) [68384-87-2] and then DMN, contained enlarged parenchymal cells (megalocytes) similar to those seen in chronic pyrrolizidine alkaloid poisoning. At this time such abnormal cells were not found in rats given any of the other pyrroles followed by DMN, or compound I and then TA or CCl4.
Toxicology Letters published new progress about Liver. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Electric Literature of 52160-51-7.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts