Liu, Hongbo; Wang, Wenxiao; Gao, Xingjuan published their research in Experimental and Therapeutic Medicine on December 31 ,2020. The article was titled 《Comparison of the efficacy of ambroxol hydrochloride and N-acetylcysteine in the treatment of children with bronchopneumonia and their influence on prognosis》.Formula: C13H19Br2ClN2O The article contains the following contents:
The aim of the present study was to compare the efficacy of ambroxol hydrochloride and N-acetylcysteine in the treatment of children with bronchial pneumonia and their influence on prognosis. A total of 120 children with bronchial pneumonia, admitted to The Affiliated Yantai Yuhuangding Hospital of Qingdao University from July 2015 to August 2018, were enrolled in the study. Among them, 58 children were treated with N-acetylcysteine and comprised the exptl. group, and 62 children were treated with ambroxol hydrochloride and comprised the control group. Children’s phys. signs (such as fever, short breath, cough and pulmonary rales) and the adverse reactions to treatment were observed, and the disappearance time of the signs was recorded. In addition, the cellular immune function indicators and the quality of life after treatment were investigated. There was no significant difference in clin. data between the two groups (P>0.05). The effective rate in the exptl. group was significantly higher than that in the control group (P<0.05). The disappearance time of symptoms, such as fever, cough, asthma and rales in the lung, was significantly shorter in the exptl. group than that in the control group (P<0.05). The hospitalization time of patients in the exptl. group was shorter than that in the control group (P<0.05). After treatment, IgA (IgA), IgG (IgG), IgM (IgM) and complement C3 were significantly increased in the exptl. group (P<0.01), and the IgA and IgG in the exptl. group were significantly higher than those in the control group (P<0.01). The incidence of adverse reactions in the exptl. group was significantly lower than that in the control group (P<0.05). In conclusion, N-acetylcysteine has a significant effect on the treatment of bronchopneumonia in children providing a quick relief from symptoms, such as lung rales, and therefore is worthy of use in clinic. In the experiment, the researchers used many compounds, for example, trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Formula: C13H19Br2ClN2O)
trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Formula: C13H19Br2ClN2O Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.
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