《Isoquinolinequinone N-oxides as anticancer agents effective against drug resistant cell lines》 was written by Kruschel, Ryan D.; Buzid, Alyah; Khandavilli, Udaya B. Rao; Lawrence, Simon E.; Glennon, Jeremy D.; McCarthy, Florence O.. Reference of 4-Aminobutan-1-ol And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:
The structured development of isoquinolinequinones I [R = Me, (CH2)4OH, Bn; RR1 = (CH2)2OCH(Et)CH2; R2 = H, Br] and their N-oxides II anticancer framework which exhibited growth inhibition in the nM range across melanoma, ovarian and leukemia cancer cell lines was reported. A new lead compound Me 6-(benzylamino)-1,3-dimethyl-2-oxido-5,8-dioxo-isoquinolin-2-ium-4-carboxylate exhibited nM GI50 values against 31/57 human tumor cell lines screened as part of the NCI60 panel and showed activity against doxorubicin resistant tumor cell lines. An electrochem. study highlighted a correlation between electropositivity of the isoquinolinequinone N-oxide framework and cytotoxicity. Adduct binding to sulfur based biol. nucleophiles glutathione and cysteine was observed in vitro. This new framework possessed significant anticancer potential.4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol) was used in this study.
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Reference of 4-Aminobutan-1-ol
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