《Highly enantioselective oxidation of racemic phenyl-1,2-ethanediol to optically pure (R)-(-)-mandelic acid by a newly isolated Brevibacterium lutescens CCZU12-1》 was written by He, Yu-Cai; Ma, Cui-Luan; Zhang, Xian; Li, Liang; Xu, Jian-He; Wu, Miao-Xin. HPLC of Formula: 133082-13-0 And the article was included in Applied Microbiology and Biotechnology on August 31 ,2013. The article conveys some information:
Enantioselective oxidation of racemic phenyl-1,2-ethanediol into (R)-(-)-mandelic acid by a newly isolated Brevibacterium lutescens CCZU12-1 was demonstrated. It was found that optically active (R)-(-)-mandelic acid (e.e.p > 99.9 %) is produced leaving the other enantiomer (S)-(+)-phenyl-1,2-ethanediol intact. Using fed-batch method, a total of 172.9 mM (R)-(-)-mandelic acid accumulated in the reaction mixture after the seventh feed. Moreover, oxidation of phenyl-1,2-ethanediol using calcium alginate-entrapped resting cells was carried out in the aqueous system, and efficient biocatalyst recycling was achieved as a result of cell immobilization in calcium alginate, with a product-to-biocatalyst ratio of 27.94 g (R)-(-)-mandelic acid g-1 dry cell weight cell after 16 cycles of repeated use. The experimental process involved the reaction of (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0HPLC of Formula: 133082-13-0)
(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.HPLC of Formula: 133082-13-0
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts