《Facile and expedient synthesis of α,β-unsaturated isoxazol-5(4H)-ones under mild conditions》 was published in Research on Chemical Intermediates in 2020. These research results belong to Ghorbani, Fatemeh; Kiyani, Hamzeh; Pourmousavi, Seied Ali. Related Products of 100-83-4 The article mentions the following:
It was found that nano-SiO2-H2SO4 was catalyzed the three-component cyclocondensation of aryl/heteroaryl aldehydes, hydroxylamine hydrochloride and β-ketoesters toward the synthesis of α,β-unsaturated isoxazol-5(4H)-ones under green conditions. The reaction yielded the corresponding heterocycles at room temperature in relatively shorter reaction times. It merits mentioning that the mild conditions allowed the synthesis of several α,β-unsaturated isoxazol-5(4H)-ones using this method. Some new derivatives of isoxazolones were also synthesized and characterized. It was efficient, clean, simple, safe and ecol. friendly. This straightforward method was cost-effective and required no preparation of reactants. The three-component annulation was performed without using energy sources, for example heat, ultrasound wave, and microwave irradiation The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxybenzaldehyde(cas: 100-83-4Related Products of 100-83-4)
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Related Products of 100-83-4
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