Cai, Yuan; Shi, Shi-Liang published their research in Journal of the American Chemical Society in 2021. The article was titled 《Enantioconvergent Arylation of Racemic Secondary Alcohols to Chiral Tertiary Alcohols Enabled by Nickel/N-Heterocyclic Carbene Catalysis》.Application of 24388-23-6 The article contains the following contents:
The direct upgrading reaction of simple and readily available achiral alcs. via C-H functionalization is an ideal strategy to prepare value-added chiral higher alcs. Herein, the first enantioconvergent upgrading reaction of simple racemic secondary alcs. to enantioenriched tertiary alcs were disclosed. An N-heterocyclic carbene (NHC)-nickel catalyst was leveraged to enable this highly efficient formal asym. alc. α-C-H arylation via a dehydrogenation using Ph triflate as a mild oxidant followed by asym. addition of arylboronic esters to the transient ketones. Mechanistic studies and control experiments were conducted to reveal the possible reasons for the exceptional control over chemo- and enantioselectivity. The results came from multiple reactions, including the reaction of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Application of 24388-23-6)
4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Application of 24388-23-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts