Burns, Michael; Bi, Wenying; Kim, Hui; Lall, Manjinder S.; Li, Chao; O’Neill, Brian T. published the artcile< Ketoreductase/Transaminase, One-Pot, Multikilogram Biocatalytic Cascade Reaction>, Recommanded Product: But-3-en-1-ol, the main research area is biocatalytic cascade reaction ketoreductase transaminase.
A biocatalytic cascade to produce tert-Bu ((2R,4R)-2-methyltetrahydro-2H-pyran-4-yl)carbamate has been demonstrated at the multikilogram scale. In this reaction, a racemic ketone is resolved by reducing the undesired ketone using a ketone reductase (KRED). The reduction is stereospecific for the 2-position of substrate (2S)-ketone leaving the (2R)-ketone unreacted. After the (2S)-ketone has been depleted, a transaminase is added to catalyze the enantioselective transamination of the ketone, resulting in formation of the (2R, 4R)-amine 6. The product is recovered from the aqueous reaction after Boc protection.
Organic Process Research & Development published new progress about Biochemical reaction kinetics. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts