Brain, K. R.; Green, D. M.; Jones, A. C.; Walters, K. A.; Api, A. M.; Selechnik, D.; Joshi, K. published the artcile< In vitro human skin absorption of linalool: Effects of vehicle composition, evaporation and occlusion on permeation and distribution>, Synthetic Route of 78-70-6, the main research area is Linalool; Occlusion; Vehicle effects.
In vitro human skin permeation and distribution of the fragrance material linalool (3,7-dimethyl-1,6-octadien-3-ol, CAS Number 78-70-6) following application in a range of single and mixed vehicles was determined, under unoccluded and occluded conditions, using human epidermal membranes. Vehicles were (70/30 volume/volume) ethanol[EtOH]/water, dipropyleneglycol [DPG], di-Et phthalate [DEP], (25/75 volume/volume) EtOH/DEP, (25/75 volume/volume) EtOH/DPG and petrolatum. Worst case absorbed dose values (% applied dose) for linalool under unoccluded conditions varied from 1.84% (DPG) to 4.08% (EtOH/water) and under occluded conditions from 5.9% (DEP) to 14.7% (EtOH/water). Occlusion always increased absorption but the magnitude of the effect varied with the vehicle from 2 to 6-fold. This study demonstrated that in vitro human skin permeation of linalool varied quite widely between test vehicles and that the magnitude of the effect of occlusion was also vehicle dependent. This was particularly significant in view of the reported variations in biol. responses using different vehicles (Lalko et al., 2004; Politano et al., 2006).
International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Synthetic Route of 78-70-6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts