《Transition metal-free, base mediated one-pot approach for the construction of the benzo[b][1,4,5]oxathiazepine 1-oxide core》 was published in Organic & Biomolecular Chemistry in 2022. These research results belong to Banerjee, Arpita; Panda, Gautam. Computed Properties of C3H6O2 The article mentions the following:
Herein, a base mediated, transition metal-free intermol. epoxide ring opening by the nucleophilic attack of ortho-halogenated NH-sulfoximine followed by intramol. aromatic nucleophilic substitution (SNAr) for the synthesis of separable diastereomers of selected benzo[b][1,4,5]oxathiazepine 1-oxides I [R1 = Me, Et, cyclopentyl, etc.; R2 = CH:CH2, Ph, 2-naphthyl, etc.] was developed. Both C-N and C-O bonds were formed simultaneously in a single step. This strategy had a good substrate scope and required simple reaction conditions (room temperature) and cost-effective reagents, and showed good applicability for accessing sulfoximine analogs of benzoxathiazepine 1-oxide like bioactive skeletons. The absolute configurations of the separable major isomer I [R1 = n-Pr; R2 = CH2OCH2C6H5; stereo = R,R] minor isomer I [R1 = n-Pr; R2 = CH2OCH2C6H5; stereo = R,S] and single isomer II were confirmed by 2D NMR. On the other hand, the relative configuration of compound I [R1 = i-Pr; R2 = 4-ClC6H4] was assigned by 2D NMR along with X-ray crystal data anal. The results came from multiple reactions, including the reaction of (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Computed Properties of C3H6O2)
(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Computed Properties of C3H6O2
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