The author of 《Potential antitumor agents. 12. 2-Formyl-4-aminophenylpyridine thiosemicarbazones》 were Agrawal, Krishna C.; Booth, Barbara A.; DeNuzzo, Suzanne M.; Sartorelli, Alan C.. And the article was published in Journal of Medicinal Chemistry in 1975. Application In Synthesis of (4-Phenylpyridin-2-yl)methanol The author mentioned the following in the article:
Title compounds 4-(o-aminophenyl)- [55218-89-8], 4-(p-aminophenyl)- [55218-90-1], and 4-(m-aminophenyl)-2-formylpyridine thiosemicarbazone (I) [52583-84-3] were prepared from 4-phenylpyridine [939-23-1] by methylation with MeLi, nitration, separation of isomers as HCl or HNO3 salts, N-oxidation, rearrangement with Ac2O, hydrolysis, and oxidation of the resulting carbinol of the nitro group and reaction with thiosemicarbazide. Of the title compounds, only I was active, increasing the life span of mice bearing Sarcoma 180 ascites cells by ∼20 days. 2-Formyl-4-phenylpyridine thiosemicarbazone [55218-79-6] was only marginally active in the mouse sarcoma test. Structure-activity relations are discussed. In addition to this study using (4-Phenylpyridin-2-yl)methanol, there are many other studies that have used (4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0Application In Synthesis of (4-Phenylpyridin-2-yl)methanol) was used in this study.
(4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Application In Synthesis of (4-Phenylpyridin-2-yl)methanol
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