COA of Formula: C6H7BO3In 2022 ,《GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1》 appeared in Journal of Medicinal Chemistry. The author of the article were Taylor, Alexander M.; Bailey, Chris; Belmont, Lisa D.; Campbell, Robert; Cantone, Nico; Cote, Alexandre; Crawford, Terry D.; Cummings, Richard; DeMent, Kevin; Duplessis, Martin; Flynn, Megan; Good, Andrew C.; Huang, Hon-Ren; Joshi, Shivangi; Leblanc, Yves; Murray, Jeremy; Nasveschuk, Christopher G.; Neiss, Adrianne; Poy, Florence; Romero, F. Anthony; Sandy, Peter; Tang, Yong; Tsui, Vickie; Zawadzke, Laura; Sims, Robert J. III; Audia, James E.; Bellon, Steven F.; Magnuson, Steven R.; Albrecht, Brian K.; Cochran, Andrea G.. The article conveys some information:
Bromodomains are acetyllysine recognition domains present in a variety of human proteins. Bromodomains also bind small mols. that compete with acetyllysine, and therefore bromodomains have been targets for drug discovery efforts. Highly potent and selective ligands with good cellular permeability have been proposed as chem. probes for use in exploring the functions of many of the bromodomain proteins. We report here the discovery of a class of such inhibitors targeting the family VIII bromodomains of SMARCA2 (BRM) and SMARCA4 (BRG1), and PBRM1 (polybromo-1) bromodomain 5. We propose one example from this series, GNE-064, as a chem. probe for the bromodomains SMARCA2, SMARCA4, and PBRM1(5) with the potential for in vivo use. In the experimental materials used by the author, we found 2-Hydroxyphenylboronic acid(cas: 89466-08-0COA of Formula: C6H7BO3)
2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. COA of Formula: C6H7BO3
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