Category: alcohols-buliding-blocksIn 2020 ,《Sulfone-Mediated SNAr Reaction as a Powerful Tool for the Synthesis of 4-Quinolinyl Ethers and More-Application to the Synthesis of HCV NS3/4a Protease Inhibitor BI 201420》 appeared in Journal of Organic Chemistry. The author of the article were Patel, Nitinchandra D.; Wei, Xudong; Byrne, Denis; Narayanan, Bikshandarkoil A.; Pennino, Scott; Sarvestani, Max; Saha, Anjan; Haddad, Nizar; Kapadia, Suresh; Lorenz, Jon C.; DeCroos, Philomen; Ye, Andrew; Lee, Heewon; Grinberg, Nelu; Hossain, Azad; Busacca, Carl A.; Yee, Nathan K.; Senanayake, Chris H.. The article conveys some information:
4-Sulfonylquinolines and a 4-sulfonylpyridine underwent chemoselective nucleophilic aromatic substitution reactions with alcs. using either potassium tert-butoxide or potassium hexamethyldisilazide (when tertiary alcs. were used) in DMF to yield quinolinyl or pyridinyl ethers. Using this method, quinolinyl ether-containing HCV NS3/4a protease inhibitors BI 201420MU, BILN2061, and a related macrocyclic HCV protease inhibitor were prepared convergently. After reading the article, we found that the author used trans-4-Aminocyclohexanol(cas: 27489-62-9Category: alcohols-buliding-blocks)
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts