《Syntheses and anti-HIV and human cluster of differentiation 4 (CD4) down-modulating potencies of pyridine-fused cyclotriazadisulfonamide (CADA) compounds》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Lumangtad, Liezel A.; Claeys, Elisa; Hamal, Sunil; Intasiri, Amarawan; Basrai, Courtney; Yen-Pon, Expedite; Beenfeldt, Davison; Vermeire, Kurt; Bell, Thomas W.. Recommanded Product: 1195-59-1 The article mentions the following:
CADA compounds selectively down-modulate human cell-surface CD4 protein and are of interest as HIV entry inhibitors and as drugs for asthma, rheumatoid arthritis, diabetes and some cancers. Postulating that fusing a pyridine ring bearing hydrophobic substituents into the macrocyclic scaffold of CADA compounds may lead to potent compounds with improved properties, 17 macrocycles were synthesized, 14 with 12-membered rings having an isobutylene head group, two arenesulfonyl side arms, and fused pyridine rings bearing a para substituent. The analogs display a wide range of CD4 down-modulating and anti-HIV potencies, including some with greater potency than CADA, proving that a highly basic nitrogen atom in the 12-membered ring is not required for potency and that hydrophobic substituents enhance potency of pyridine-fused CADA compounds Cytotoxicities of the new compounds compared favorably with those of CADA, showing that incorporation of a pyridine ring into the macrocyclic scaffold can produce selective compounds for potently down-modulating proteins of medicinal interest. In the experiment, the researchers used 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 1195-59-1)
2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Recommanded Product: 1195-59-1
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts