Kotb, Ahmed’s team published research in European Journal of Medicinal Chemistry in 2018 | CAS: 18621-18-6

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Computed Properties of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Computed Properties of C3H8ClNOIn 2018 ,《Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity》 was published in European Journal of Medicinal Chemistry. The article was written by Kotb, Ahmed; Abutaleb, Nader S.; Seleem, Mohamed A.; Hagras, Mohamed; Mohammad, Haroon; Bayoumi, Ashraf; Ghiaty, Adel; Seleem, Mohamed N.; Mayhoub, Abdelrahman S.. The article contains the following contents:

(Tert-butylphenyl)thiazolylpyrimidines I [R = H2N, MeNH, 1-pyrrolidinyl, 3-pyridinyl, EtNH, cyclopentylamino, cyclohexylamino, Me2N, 1-azetidinyl, 3-hydroxy-1-azetidinyl, 4-morpholinyl, H2NCH2CH2NH, H2NNH, tetramethylguanidinyl, R1C(:NH)NH; R1 = H2N, MeNH, Me2N, 1-pyrrolidinyl, 4-morpholinyl, 4-methyl-1-piperazinyl, 3-pyridinyl, 2-pyridinyl] were prepared as antibacterial agents and tested against methicillin-resistant Staphylococcus aureus (MRSA). I [R = H2NCH2CH2NH, R1C(:NH)NH; R1 = Me2N, 4-morpholinyl, 3-pyridinyl, 2-pyridinyl] were tested against vancomycin-resistant Staphylococcus aureus, methicillin- and cephalosporin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus epidermidis, Enterococcus faecalis, and Listeria monocytogenes, were tested for toxicity to human colorectal cells, and were tested for activity against MRSA biofilms. I (R = H2NCH2CH2NH) was tested for its stimulation of resistance in MRSA and for its pharmacokinetic properties (half-life, clearance, volumes fo distribution). The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Computed Properties of C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Computed Properties of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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