In 2018,Journal of Medicinal Chemistry included an article by Degorce, Sebastien L.; Bodnarchuk, Michael S.; Cumming, Iain A.; Scott, James S.. Recommanded Product: 27489-62-9. The article was titled 《Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines》. The information in the text is summarized as follows:
In this article, we report our investigation of a phenomenon by which bridging morpholines across the ring with one-carbon tethers leads to a counterintuitive reduction in lipophilicity. This effect was also found to occur in piperazines and piperidines and lowered the measured log D7.4 of the bridged mols. by as much as -0.8 relative to their unbridged counterparts. As lowering lipophilicity without introducing addnl. heteroatoms can be desirable, we believe this potentially provides a useful tactic to improve the drug-like properties of mols. containing morpholine-, piperazine-, and piperidine-like motifs. The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9Recommanded Product: 27489-62-9)
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Recommanded Product: 27489-62-9
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts