Bogdanov, A. V.; Gazizov, A. S.; Smolobochkin, A. V.; Mironov, V. F. published an article on January 31 ,2019. The article was titled 《Synthesis of New (2-Acetamido)phenylglyoxylamides Containing an Acetal Fragment》, and you may find the article in Russian Journal of Organic Chemistry.Safety of 4,4-Diethoxybutan-1-amine The information in the text is summarized as follows:
Mild opening of the five-membered ring in 1-acetylisatins by the action of an equimolar amount of 4,4-diethoxybutan-1-amine afforded 2-(2-acetamidophenyl)-N-(4,4-diethoxybutyl)-2-oxoacetamides in almost quant. yield. In the experiment, the researchers used 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Safety of 4,4-Diethoxybutan-1-amine)
4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Safety of 4,4-Diethoxybutan-1-amine
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts