Badhani, Gaurav; Joshi, Abhisek; Adimurthy, Subbarayappa published an article in 2021. The article was titled 《Ionic-Liquid-Catalyzed Synthesis of Imines, Benzimidazoles, Benzothiazoles, Quinoxalines and Quinolines through C-N, C-S, and C-C Bond Formation》, and you may find the article in European Journal of Organic Chemistry.Name: 3-Pyridinemethanol The information in the text is summarized as follows:
The tetra-Me ammonium hydroxide catalyzed oxidative coupling of amines RNH2 (R = Ph, cyclohexyl, pentyl, etc.) and alcs. R1CH2OH (R1 = Ph, 4-pyridyl, 2-naphthyl, etc.) for the synthesis of imines RN=CHR1 under metal-free conditions by utilizing oxygen from air as the terminal oxidant has been described. Under the same conditions, with ortho-phenylene diamines 1,2-(NH2)2C6H3R2 (R2 = 3-Me, 4,5-(Me)2, 4-F, etc.) and 2-aminobenzenethiols like 2-aminobenzenethiol and 2-amino-4-chlorobenzenethiol the corresponding benzimidazoles I (R3 = 6-Me, 5,6-Me2, 5-Cl, etc.; X = NH) and benzothiazoles I (R3 = H, 5-Cl; X = S) were obtained. Quinoxalines II (R4 = H, 6-Me, 6,7-Me2, 6-Cl, 6-F; Y = N) were obtained from ortho-phenylene diamines and 1-phenylethane-1,2-diol, and the conditions were then extended to the synthesis of quinoline building blocks II (R4 = 4-ClC6H4, 4-BrC6H4, 4-MeOC6H4, 2-naphthyl; Y = CH) by reaction of 2-amino benzyl alcs. like 2-aminobenzenemethanol either with 1-phenylethan-1-ol or acetophenone derivatives R4COMe. The formation of C-N, C-S and C-C bonds was achieved under metal-free conditions. A broad range of amines (aromatic, aliphatic, cyclic and heteroaromatic) as well as benzylic alcs. including heteroaryl alcs. reacted smoothly and provided the desired products. The mild reaction conditions, com. available catalyst, metal-free, good functional-group tolerance, broad range of products (imines, benzimidazoles, benzothiazoles, quinoxalines and quinolines) and applicability at gram scale reactions are the advantages of the present strategy. The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0Name: 3-Pyridinemethanol)
3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Name: 3-Pyridinemethanol
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