The author of 《Synthesis and Transformations of 4-Hydroxy-2-methylquinoline-6-carbohydrazide》 were Aleksanyan, I. L.; Hambardzumyan, L. P.. And the article was published in Russian Journal of Organic Chemistry in 2019. Related Products of 100-83-4 The author mentioned the following in the article:
A substituted quinoline-6-carbohydrazide I (R = H) was synthesized by the reaction of Et 4-hydroxy-2-methylquinoline-6-carboxylate with hydrazine hydrate. The quinoline-6-carbohydrazide I (R = H) was reacted with Ph isothiocyanate to obtain the corresponding phenylhydrazinecarbothioamide I (R = C6H5NHC(S)). The intramol. cyclization of the latter in alk. and acidic media gave quinolyl-substituted triazole as 5-(4-hydroxy-2-methyl-quinolin-6-y)-4-phenyl-2,4-dihydro-[1,2,4]triazole-3-thione and thiadiazole as 2-methyl-6-(5-phenylamino-[1,3,4]thiadiazol-2-yl)-quinolin-4-ol. The reaction of the quinoline-6-carbohydrazide I (R = H) with carbon disulfide in alk. media yielded a quinolyl-substituted 1,3,4-oxadiazole 2-(5-mercapto-[1,3,4]oxadiazol-2-yl)-6-methyl-quinolin-4-ol, and the reactions of the same reagent with substituted benzaldehydes R1C6H4CHO (R1 = 2-OH, 3-OH, 4-OH, 4-(CH3)2N) gave N’-(substituted benzylidene)quinoline-6-carbohydrazides II. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxybenzaldehyde(cas: 100-83-4Related Products of 100-83-4)
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Related Products of 100-83-4
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