Plestina, R.; Stoner, H. B.; Jones, Glenys; Butler, W. H.; Mattocks, A. R. published the artcile< Vascular changes in the lungs of rats after the intravenous injection of pyrrole carbamates>, Application of C6H9NO, the main research area is lung pathol pyrrole carbamate; monocrotaline derivative lung toxicity; alkaloid pyrrolizidine derivative lung.
Acute pulmonary edema was produced in mice and rats, after injection into a systemic vein, of 1-methyl-2-(N-ethylcarbamoyloxymethyl)pyrrole (I) [62435-67-0] and 1-methyl-2,3-bis(N-ethylcarbamoyloxymethyl)pyrrole (II) [36504-91-3], 2 synthetic compounds related to monocrotaline pyrrole. 1-Methyl-2-hydroxymethylpyrrole (III) [52160-51-7] and Et N-ethylcarbamate [623-78-9] had no such effect and although 3-(N-ethylcarbamoyloxymethyl)furan (IV) [50884-33-8] did not cause pleural effusion in rats it did in mice. Like monocrotaline pyrrole, the pyrrole carbamates, when injected into other vessels, produced edema in the region of the 1st capillary bed encountered. S labeling occurred in both the postcapillary venules and the capillaries of the lungs when colloidal C was injected i.v. after the pyrrole carbamates. Venular labeling occurred before capillary labeling, which occurred optimally when C was injected >4 h after the pyrrole. No C labeling was observed after IV injection. The effects of the synthetic pyrrole esters were similar to those of monocrotaline pyrrole. The pyrrole carbamates were less active on a mol. basis, but they had a broader action on the pulmonary vasculature, causing both venular and capillary labeling. The compounds required the pyrrole ring structure and ≥1 ester side-chain to affect the lungs acutely.
Journal of Pathology published new progress about Lung. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Application of C6H9NO.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts