Zhong, Lin-Fang; Shang, Zhi-Chun; Sun, Fu-Juan; Zhu, Pan-Hu; Yin, Yong; Kong, Ling-Yi; Yang, Ming-Hua published the artcile< Anticandidal formyl phloroglucinol meroterpenoids: Biomimetic synthesis and in vitro evaluation>, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde, the main research area is formyl phloroglucinol meroterpenoid preparation anticandidal antibiofilm; Antibiofilm activity; Anticandidal activity; Essential oil; Formyl phloroglucinol meroterpenoids.
Inspired by the diversity-oriented synthesis, some novel formyl phloroglucinol meroterpenoids were synthesized via biomimetic synthesis using essential oils. Eight of them were demonstrated with good in vitro fungicidal activity against Candida albicans and C. glabrata. Cedartriol B (I) showed the best anticandidal ability that was powerfully comparable to fluconazole when testing against several strains in vitro. The antibiofilm activity was also found for the I treating group which was evidenced to block the hyphal elongation and filamentation of C. albicans. Therefore, compound I is a promising candidate for further antifungal-based structure modification.
Bioorganic Chemistry published new progress about [4+2] Cycloaddition reaction. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts