In 2018,Zhao, Yuqiong; Lu, Yihuan; Li, Ridong; He, Jianan; Zhang, Han; Wang, Xin; Ge, Zemei; Li, Runtao published 《Discovery and optimization of 2-thio-5-amino substituted benzoquinones as potent anticancer agents》.European Journal of Medicinal Chemistry published the findings.Electric Literature of C6H13NO The information in the text is summarized as follows:
Based on our discovered novel lead compound 1 through phenotypic drug discovery (PDD) approaches, systematic structural optimization was performed. A series of 2-allylthio-5-amino substituted benzoquinones were synthesized and evaluated for their in-vitro anticancer activities against human prostate cancer cell line PC3. The compound I was found inhibit the growth of PC3 with an IC50 of 0.22 μM, which is over 20-fold improvement compared to lead compound II. It is noteworthy that compound I also showed potent anti-proliferation activity toward a panel of cancer cells with relatively less cytotoxicity to nonmalignant cell, as well as good water solubility In the part of experimental materials, we found many familiar compounds, such as trans-4-Aminocyclohexanol(cas: 27489-62-9Electric Literature of C6H13NO)
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Electric Literature of C6H13NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts