Computed Properties of C9H13NOOn November 2, 2020 ,《Site-Specific C(sp3)-H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions》 appeared in Angewandte Chemie, International Edition. The author of the article were Zhao, Rong; Fu, Kang; Fang, Yuanding; Zhou, Jia; Shi, Lei. The article conveys some information:
The utilization of N-centered radicals to synthesize nitrogen-containing compounds has attracted considerable attention recently, due to their powerful reactivities and the concomitant construction of C-N bonds. However, the generation and control of N-centered radicals remain particularly challenging. We report a tethering strategy using SOMO-HOMO-converted distonic radical anions for the site-specific aminations of imidates and amidines with aid of the non-covalent interaction. This reaction features a remarkably broad substrate scope and also enables the late-stage functionalization of bioactive mols. Furthermore, the reaction mechanism is thoroughly investigated through kinetic studies, Raman spectroscopy, ESR spectroscopy, and d. functional theory calculations, revealing that the aminations likely involve direct homolytic cleavage of N-H bonds and subsequently controllable 1,5 or 1,6 hydrogen atom transfer. The experimental part of the paper was very detailed, including the reaction process of 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Computed Properties of C9H13NO)
2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Computed Properties of C9H13NO
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