Zhao, Huaibo; McMillan, Alastair J.; Constantin, Timothee; Mykura, Rory C.; Julia, Fabio; Leonori, Daniele published the artcile< Merging Halogen-Atom Transfer (XAT) and Cobalt Catalysis to Override E2-Selectivity in the Elimination of Alkyl Halides: A Mild Route toward contra-Thermodynamic Olefins>, HPLC of Formula: 627-27-0, the main research area is Merging Halogen Atom Transfer Cobalt Catalysis Elimination Alkyl Halides.
We report here a mechanistically distinct tactic to carry E2-type eliminations on alkyl halides. This strategy exploits the interplay of α-aminoalkyl radical-mediated halogen-atom transfer (XAT) with desaturative cobalt catalysis. The methodol. is high-yielding, tolerates many functionalities, and was used to access industrially relevant materials. In contrast to thermal E2 eliminations where unsym. substrates give regioisomeric mixtures, this approach enables, by fine-tuning of the electronic and steric properties of the cobalt catalyst, to obtain high olefin positional selectivity. This unprecedented mechanistic feature has allowed access to contra-thermodn. olefins, elusive by E2 eliminations.
Journal of the American Chemical Society published new progress about Crystal structure. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, HPLC of Formula: 627-27-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts