Zhang, Zhipeng; He, Zhiqin; Xie, Yuxing; He, Tiantong; Fu, Yaofeng; Yu, Yang; Huang, Fei published the artcile< Bronsted acid-catalyzed homogeneous O-H and S-H insertion reactions under metal- and ligand-free conditions>, Application of C4H8O, the main research area is alkoxy acetate preparation; alc diazo compound OH bond insertion Bronsted acid catalyzed; phenylethylidene amino oxy acetate preparation; oximes with diazo compound OH insertion Bronsted acid catalyzed; thio aryl acetate preparation; thiol diazo compound SH insertion Bronsted acid catalyzed.
Under metal- and ligand-free conditions, the economical and accessible CF3SO3H successfully catalyzed homogeneous O-H bond insertion reactions between hydroxyl compounds and diazo compounds to afford alkoxy acetates. Including phenols, alcs., water and oximes, these O-H bond insertion reactions were very general and functional-group tolerant. Here, the O-H bond insertion of oximes (ketoximes and aldoximes) to gave phenylethylidene(amino(oxy)acetates) was reported and their structures were characterized by X-ray crystallog. Moreover, a simple and effective method for S-H insertion reactions of thiols to gave thio(aryl)acetates was also developed, delivering the desired C-S bond products with good to excellent yields. It was worth noting that the efficacy of the developed methodol. could be further shown by the expeditious synthesis of the PPAR agonist MBX-102 acid.
Organic Chemistry Frontiers published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts