Zhang, Mengxun’s team published research in Organic & Biomolecular Chemistry in 2021 | 627-27-0

Organic & Biomolecular Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Zhang, Mengxun; Chen, Tie; Fang, Shisong; Wu, Weihua; Wang, Xin; Wu, Haiqiang; Xiong, Yongai; Song, Jun; Li, Chenyang; He, Zhendan; Lee, Chi-Sing published the artcile< Peroxide- and transition metal-free electrochemical synthesis of α,β-epoxy ketones>, Quality Control of 627-27-0, the main research area is epoxy ketone preparation antitumor activity diastereoselective green chem electrochem.

A novel electrochem. method for the synthesis of α,β-epoxy ketones I (R = 2-methylphenyl, 3-iodophenyl, 2,3-dihydro-1-benzofuran-6-yl, etc.; R1 = 4-methylphenyl, 5-fluoro-2-methoxyphenyl, naphthalen-2-yl, etc.) is reported. With KI as the redox mediator, Me ketones RC(O)CH3 reacted with aldehydes R1CHO under peroxide- and transition metal-free electrolytic conditions and afforded α,β-epoxy ketones I in one pot (36 examples, 52-90% yield). This safe and environmental-friendly method has a broad substrate scope and can readily provide a variety of α,β-epoxy ketones I in gram-scales for evaluation of their anti-cancer activities.

Organic & Biomolecular Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts