Zhan, Ying; Zhao, Yao; Du, Qiang; Rui, Jiacheng; Chen, Rizhi; Zheng, Xintao; Wu, Xiaojin published the artcile< Chemo- and regioselective nucleophilic hydrofunctionalization of unactivated aliphatic alkenes under transition-metal-free catalysts>, Quality Control of 627-27-0, the main research area is beta hetero aliphatic amide preparation green chem chemoselective regioselective; unactivated terminal internal aliphatic alkene nucleophilic Markovnikov selective hydrofunctionalization.
Transition-metal-free-catalyzed nucleophilic hydrofunctionalization of both terminal and internal unactivated aliphatic alkenes has been described for the first time. Most topical classes of carbon, nitrogen and oxygen nucleophiles are well-compatible. The highly chemoselective unprotected dinucleophiles are also presented in the atom-economical approach. More than 80 structurally complex β-hetero-substituted aliphatic amides were rapidly synthesized in good yield with exclusive Markovnikov selectivity, which are difficult to be achieved efficiently by the traditional Michael addition of conjugated amides due to their poor intrinsic electrophilicity.
Green Chemistry published new progress about Addition reaction. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts