Yu, Wensheng; Fells, James; Clausen, Dane; Liu, Jian; Klein, Daniel J.; Christine Chung, C.; Myers, Robert W.; Wu, Jin; Wu, Guoxin; Howell, Bonnie J.; Barnard, Richard J. O.; Kozlowski, Joseph published their research in Bioorganic & Medicinal Chemistry Letters in 2021. The article was titled 《Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation》.Product Details of 89466-08-0 The article contains the following contents:
A series of unique macrocyclic HDACs 1, 2, and 3 selective inhibitors were identified with good enzymic activity and high selectivity over HDACs 6 and 8. These macrocyclic HDAC inhibitors used an Et ketone as the zinc-binding group. Compounds I and II stood out as leads due to their low double-digit nM EC50s in the 2C4 cell-based HIV latency reactivation assay. The PK profiles of these macrocyclic HDAC inhibitors still needed improvement. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Product Details of 89466-08-0) was used in this study.
2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Product Details of 89466-08-0
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