Product Details of 18621-18-6In 2020 ,《Discovery of a potent dual inhibitor of wild-type and mutant respiratory syncytial virus fusion proteins through the modulation of atropisomer interconversion properties》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Yamaguchi-Sasaki, Toru; Kawaguchi, Takanori; Okada, Atsushi; Tokura, Seiken; Tanaka-Yamamoto, Nozomi; Takeuchi, Tomoki; Ogata, Yuya; Takahashi, Ryo; Kurimoto-Tsuruta, Risa; Tamaoki, Tomokazu; Sugaya, Yutaka; Abe-Kumasaka, Tomoko; Arikawa, Kaho; Yoshida, Ippei; Sugiyama, Hiroyuki; Kanuma, Kosuke; Yoshinaga, Mitsukane. The article conveys some information:
The development of effective respiratory syncytial virus (RSV) fusion glycoprotein (F protein) inhibitors against both wild-type and the D486N-mutant F protein is urgently required. We recently reported a 15-membered macrocyclic pyrazolo[1,5-a]pyrimidine derivative 4 that exhibited potent anti-RSV activities against not only wild-type, but also D486N-mutant F protein. However, NMR studies revealed that the 15-membered derivative 4 existed as a mixture of atropisomers. An optimization study of the linker moiety between the 2-position of the benzoyl moiety and the 7-position of the pyrazolo[1,5-a]pyrimidine scaffold identified a 16-membered derivative 42c with an amide linker that showed a rapid interconversion of atropisomers. Subsequent optimization of the 5-position of the pyrazolo[1,5-a]pyrimidine scaffold and the 5-position of the benzoyl moiety resulted in the discovery of a potent clin. candidate 60b for the treatment of RSV infections. In addition to this study using Azetidin-3-ol hydrochloride, there are many other studies that have used Azetidin-3-ol hydrochloride(cas: 18621-18-6Product Details of 18621-18-6) was used in this study.
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Product Details of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
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