Surrati, Amal; Evseev, Sergey; Jourdan, Fabien; Kim, Dong-Hyun; Sottile, Virginie published the artcile< Osteogenic response of human mesenchymal stem cells analysed using combined intracellular and extracellular metabolomic monitoring>, Electric Literature of 87-73-0, the main research area is metabolite osteogenesis mesenchymal stem cell; Mesenchymal stem cells; Osteogenesis; Differentiation; Metabolomics; LC-MS; Metabolomics profiling.
The skeleton is a metabolically active organ undergoing continuous remodelling initiated by mesenchymal progenitors present in bone and bone marrow. Under certain pathol. conditions this remodelling balance shifts towards increased resorption resulting in weaker bone microarchitecture, and there is consequently a therapeutic need to identify pathways that could inversely enhance bone formation from stem cells. Metabolomics approaches recently applied to stem cell characterization could help identify new biochem. markers involved in osteogenic differentiation. Combined intra- and extracellular metabolite profiling was performed by liquid chromatog.-mass spectrometry (LC-MS) on human mesenchymal stem cells (MSCs) undergoing osteogenic differentiation in vitro. Using a combination of univariate and multivariate analyses, changes in metabolite and nutrient concentration were monitored in cultures under osteogenic treatment over 10 days. A subset of differentially detected compounds was identified in differentiating cells, suggesting a direct link to metabolic processes involved in osteogenic response. These results highlight new metabolite candidates as potential biomarkers to monitor stem cell differentiation towards the bone lineage.
Cellular Physiology & Biochemistry published new progress about Biomarkers. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.
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