St. Clair, Johnna Wellman; London, Erwin published the artcile< Effect of sterol structure on ordered membrane domain (raft) stability in symmetric and asymmetric vesicles>, Application of C27H44O, the main research area is sterol structure ordered membrane domain lipid raft stability; FRET; Lipid asymmetry; Liquid ordered; Steroid; Sterol.
Sterol structure influences liquid ordered domains in membranes, and the dependence of biol. functions on sterol structure can help identify processes dependent on ordered domains. In this study we compared the effect of sterol structure on ordered domain formation in sym. vesicles composed of mixtures of sphingomyelin, 1, 2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and cholesterol, and in asym. vesicles in which sphingomyelin was introduced into the outer leaflet of vesicles composed of DOPC and cholesterol. In most cases, sterol behavior was similar in sym. and asym. vesicles, with ordered domains most strongly stabilized by 7-dehydrocholesterol (7DHC) and cholesterol, stabilized to a moderate degree by lanosterol, epicholesterol and desmosterol, and very little if at all by 4-cholesten-3-one. However, in asym. vesicles desmosterol stabilized ordered domain almost as well as cholesterol, and to a much greater degree than epicholesterol, so that the ability to support ordered domains decreased in the order 7-DHC > cholesterol > desmosterol > lanosterol > epicholesterol > 4-cholesten-3-one. This contrasts with values for intermediate stabilizing sterols in sym. vesicles in which the ranking was cholesterol > lanosterol ∼ desmosterol ∼ epicholesterol or prior studies in which the ranking was cholesterol ∼ epicholesterol > lanosterol ∼ desmosterol. The reasons for these differences are discussed. Based on these results, we re-evaluated our prior studies in cells and conclude that endocytosis levels and bacterial uptake are even more closely correlated with the ability of sterols to form ordered domains than previously thought, and do not necessarily require that a sterol have a 3β-OH group.
Biochimica et Biophysica Acta, Biomembranes published new progress about Bilayer biological membrane. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Application of C27H44O.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts