Synthetic Route of C3H6O2On September 8, 2022 ,《Biological Effects of Modifications of the Englerin A Glycolate》 was published in ACS Medicinal Chemistry Letters. The article was written by Seenadera, Sarath P. D.; Long, Sarah A.; Akee, Rhone; Bermudez, Gabriela; Parsonage, Gregory; Strope, Jonathan; Peer, Cody; Figg, W. Douglas; Parker, Kathlyn A.; Beech, David J.; Beutler, John A.. The article contains the following contents:
Modifications at the glycolate moiety of englerin A were made to explore variations at the most sensitive site on the mol. for activity in the NCI 60 screen, wherein englerin A is highly potent and selective for renal cancer cells. Replacement of the glycolate by other functionalities as well as esterification of the glycolate hydroxyl yielded compounds which displayed excellent selectivity and potency compared with the natural product. TRPC4/5 ion channel experiments with five compounds showed delayed or reduced agonism with TRPC5, at much higher concentrations than englerin A. With TRPC4, these compounds all had no effect at 10 μM. The same compounds were not detectable in mouse serum after a single oral dose of 12.5 mg/kg. At 100 mg/kg p.o., no toxicity was observed, and blood levels were barely detectable. I.v. administration led to toxicity but at substantially lower doses than for englerin A.(R)-Oxiran-2-ylmethanol(cas: 57044-25-4Synthetic Route of C3H6O2) was used in this study.
(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Synthetic Route of C3H6O2
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