Sashidhara, Koneni V.; Rao, K. Bhaskara; Kushwaha, Pragati; Modukuri, Ram K.; Singh, Pratiksha; Soni, Isha; Shukla, P. K.; Chopra, Sidharth; Pasupuleti, Mukesh published an article in ACS Medicinal Chemistry Letters. The title of the article was 《Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus》.Electric Literature of C12H14O3 The author mentioned the following in the article:
A series of novel hybrids I [R = t-Bu, iso-Pr, n-propyl; R1 = 4-Me-C6H4, 4-MeO-C6H4, furan-2-yl, thiophene-2-yl; R2 = CO2Et, 4-MeO-C6H4, 3,4-dimethoxyphenyl.] possessing chalcone and thiazole moieties were synthesized and evaluated for their antibacterial activities. In general this class of hybrids exhibited potency against Staphylococcus aureus, and in particular, compound I [R = t-Bu, R1 = 4-Me-C6H4, R2 = 3,4-dimethoxyphenyl.] exhibited potent inhibitory activity with respect to other synthesized hybrids. Furthermore, the hemolytic and toxicity data demonstrated that the compound I [R = t-Bu, R1 = 4-Me-C6H4, R2 = 3,4-dimethoxyphenyl.] was nonhemolytic and nontoxic to mammalian cells. The in vivo studies utilizing a S. aureus septicemia model demonstrated that compound I [R = t-Bu, R1 = 4-Me-C6H4, R2 = 3,4-dimethoxyphenyl.] was as potent as vancomycin. The results of antibacterial activities underscore the potential of this scaffold that can be utilized for developing a new class of novel antibiotics. In the part of experimental materials, we found many familiar compounds, such as 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Electric Literature of C12H14O3)
5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Electric Literature of C12H14O3Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).
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