Sandberg-Gertzen, H.; Kjellander, J.; Sundberg-Gillaa, B.; Jaarnerot, G. published the artcile< In vitro effects of sulphasalazine, azodisal sodium, and their metabolites on Clostridium difficile and some other fecal bacteria>, Quality Control of 6054-98-4, the main research area is Clostridium sulphasalazine azodisal sodium sensitivity; fecal bacteria sulphasalazine azodisal sodium sensitivity.
The effects of sulphasalazine (SASP), azodisal sodium (ADS), and their metabolites were tested in vitro on aerobic and anaerobic fecal bacterial strains. Sulphapyridine (SP) had a mild-to-moderate effect on Escherichia coli and Streptococcus faecalis. SASP also had a growth-inhibitory effect on S. faecalis. The other substances had no effect on aerobic strains. SASP, SP, 5-aminosalicylic acid, and, to a certain extent, N-acetyl-5-aminosalicylic acid exerted a growth-inhibitory effect on anaerobic strains. Of special interest was the inhibitory effect on Clostridium difficile strains. Some studies suggested that SASP treatment could predispose to C. difficile superinfection, whereas others found SASP more probable to exert a prophylactic effect. The findings support the theory that SASP treatment reduces rather than promotes the risk of C. difficile superinfection.
Scandinavian Journal of Gastroenterology published new progress about Clostridium difficile. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Quality Control of 6054-98-4.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts