《Mild and Chemoselective Thioacylation of Amines Enabled by the Nucleophilic Activation of Elemental Sulfur》 was written by Saito, Masato; Murakami, Sho; Nanjo, Takeshi; Kobayashi, Yusuke; Takemoto, Yoshiji. Reference of 4-Aminobutan-1-ol And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:
A mild and chemoselective method for the thioacylation of amines using α-keto acids and elemental sulfur has been developed. The key to the success of this transformation is the nucleophilic activation of elemental sulfur by thiols such as 1-dodecanethiol. A variety of functional groups, including unprotected hydroxyl, carboxyl, amide, sulfide, and tertiary amine moieties, are tolerated under the applied reaction conditions. To demonstrate the advantages of this method compared with conventional O-S exchange reactions using Lawesson’s reagent or P2S5, thioamide moieties were introduced site-specifically into biol. active compounds After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol)
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Reference of 4-Aminobutan-1-ol
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