In 2019,European Journal of Medicinal Chemistry included an article by Pisani, Leonardo; Iacobazzi, Rosa Maria; Catto, Marco; Rullo, Mariagrazia; Farina, Roberta; Denora, Nunzio; Cellamare, Saverio; Altomare, Cosimo Damiano. Formula: C3H7BrO. The article was titled 《Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors》. The information in the text is summarized as follows:
Herein we envisaged the possibility of exploiting alkyl nitrates as precursors of alc.-bearing dual inhibitors targeting acetylcholinesterase (AChE) and monoamine oxidase B (MAO B), key enzymes in neurodegenerative syndromes such as Alzheimer’s disease (AD), through biotransformation unmasking an alc. function upon nitric oxide (NO) release. The cooperation to neuroprotection of low fluxes of NO and target enzymes’ inhibition by the alc. metabolites might return a multitargeting effect. The in vitro screening towards ChEs and MAOs of a collection of 21 primary alcs. disclosed a subset of dual inhibitors, among which three diverse chemotypes were selected to study the corresponding nitrates. Nitrate 14 proved to be a brain permeant, potent AChE-MAO B inhibitor by itself. Moreover, it protected human SH-SY5Y lines against rotenone and hydrogen peroxide with a poor inherent cytotoxicity and showed a slow conversion profile to its alc. metabolite 9d that still behaved as bimodal and neuroprotective mol. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Formula: C3H7BrO)
3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Formula: C3H7BrO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts